2024 Homeostatic theory of drug tolerance

Homeostatic theory of drug tolerance

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August undefined, 2024

Web1 jan. 2011 · In the homeostatic and redundancy theory of tolerance and dependence, W. R. Martin (1968) proposed that tolerance and dependence are part of the same phenomena. He postulated that the neuroadaptive mechanisms that counteract an effect of the drug to produce drug tolerance persist even after the drug has been cleared. WebDrug tolerance is a measurable endophenotype of addiction that can be easily generated and detected in animal models. The counteradaptive theory for drug dependence postulates that the homeostatic adaptations that produce drug tolerance become counteradaptive after drug clearance, resulting in symptoms of dependence.

Drugs and Behavior An Introduction to Behavioral Pharmacology …

WebCross tolerance – a person who has developed a tolerance to, for example, heroin, shows increased tolerance to the whole class of drugs known as opiates (YSAS 2001). Homeostasis When a psychoactive drug is consumed, it alters the levels of neurotransmitters in the synapse. hypertherm water separator

Homeostatic theory of drug tolerance: a general model of …

Web1 jan. 2001 · Homeostatic control of neural activity: a Drosophila model for drug tolerance and dependence. Ghezzi A , Atkinson NS Int Rev Neurobiol , 99:23-50, 01 Jan 2011 Web7 mei 1988 · The model assumes the development of tolerance to a repeatedly administered drug to be the result of a regulated adaptive process. The oral detection and analysis of exogenous substances is proposed to be the primary stimulus for the mechanism of drug tolerance. Web20 jun. 2024 · Homeostasis is your body's natural state of balance. The brain oversees the body's homeostasis, making adjustments to maintain a healthy, functioning system. 1 In homeostasis, your brain is able to respond and adapt to its environment smoothly and constructively. hypertherm vwi

(PDF) A DNA Element Regulates Drug Tolerance and

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WebPoulos CX, Cappell H (1991) Homeostatic theory of drug tolerance: a general model of physiological adaptation. Psychol Rev 98:390–408 Article PubMed Google Scholar Ritzmann RF, Tabakoff B (1976) Body temperature in mice: a quantitative measure of alcohol tolerance and physical dependence. J Pharmacol Exp Ther 199:158–170 … Web23 sep. 2013 · The 6b element is a homeostatic regulator of BK channel gene expression and is the first cis-acting DNA element shown to specifically affect the duration of a drug action. The time course analysis ... hypertherm water tubeWebMartin, W. R., 1968, A homeostatic and redundancy theory of tolerance to and dependence on narcotic analgesics, in The Addictive States: Research Publications of the Association for Research in Nervous and Mental Disease, Vol. 46 ( A. Wikler, Ed.), pp. 206–223. Williams & Wilkins, Baltimore, Maryland. Google Scholar. hypertherm warranty info

"Web1 dec. 2008 · Drug addiction can be defined by a compulsion to seek and take drug and the loss of control in limiting intake, and the excessive drug-taking derives from multiple motivational mechanisms. One such mechanism is the emergence of a negative emotional state when access to the drug is prevented, reflecting hedonic homeostatic dysregulation. " - Homeostatic theory of drug tolerance

Homeostatic theory of drug tolerance

Receptor regulation as a unitary mechanism for drug tolerance …

Web1 apr. 2000 · Hedonistic homeostatic dysregulation is a neuropsychological behavioural disorder associated with substance misuse and addiction. The disorder has been recognised as a consequence of dopamine replacement therapy (DRT) in 15 patients with Parkinson's disease. The syndrome typically develops in male patients with early onset … Web1 aug. 1991 · Homeostatic theory of drug tolerance: A general model of physiological adaptation PubMed Authors: Constantine X Poulos Howard Cappell Abstract At the heart of homeostatic theory is the idea...

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Web29 dec. 2024 · Pharmacodynamic tolerance arises from adjustments made by the body to compensate for an effect caused by the continued presence of a drug. These adjustments are brought about through... Web1 jan. 2011 · In the homeostatic and redundancy theory of tolerance and dependence, W. R. Martin (1968) proposed that tolerance and dependence are part of the same phenomena. He postulated that the neuroadaptive mechanisms that counteract an effect of the drug to produce drug tolerance persist even after the drug has been cleared.

Web23 dec. 2024 · Solomon and Corbit’s model, based on a homeostatic theory of emotion regulation, would explain the effects of drug consumption: its tolerance, and withdrawal, as consequences of the dysregulation that drug intake provokes in an organism and its homeostatic reaction to it. Web1 sep. 1998 · The importance of internal stimuli (pharmacological cues and interoceptive cues inherent in self-administration) to the acquisition of drug tolerance and the expression of withdrawal symptoms and the importance of conditional compensatory responses mediating CCRs is indicated. Expand 172 PDF View 4 excerpts, cites background Save …

Web1 jan. 2011 · Drug tolerance is a measurable endophenotype of addiction that can be easily generated and detected in animal models. The counteradaptive theory for drug dependence postulates that the homeostatic adaptations that produce drug tolerance become counteradaptive after drug clearance, resulting in symptoms of dependence. Web21 mrt. 2013 · The current article argues for an integrated view of addiction in the form of a homeostatic neuroadaptation model which emphasizes the motivational significance of both the positive affective state produced by opiates and the negative affective state characteristic of drug withdrawal.

Web11 apr. 2024 · Physical activity, while less necessary for survival in modern times, is still essential for thriving in life, and low levels of movement are related to numerous physical and mental health problems. However, we poorly understand why people move on a day-to-day basis and how to promote greater energy expenditure. Recently, there has been a …

Web21 aug. 2004 · Poulos and Cappell augmented Siegel's theory of drug tolerance by incorporating homeostasis, which was adopted by Siegel (Poulos and Cappell, 1991; Siegel, 1996; Siegel and Allan, 1998). The present paper presents a model of drug tolerance and dependence which is different from the theories described above. The model is based … hypertherm websiteWeb1 jan. 2001 · This review examines the development of the unitary hypothesis that both drug tolerance and the drug withdrawal syndrome arise from adaptive regulation of drug receptors in the brain. hypertherm warehouseWeb1 mei 1996 · Drug addiction is usually defined as compulsion to take a drug with loss of control over drug intake. The term substance dependence is used to describe a syndrome basically equivalent to addiction and the diagnostic criteria used describe symptoms that lead to loss of control in drug intake. Substance use, substance abuse, and substance … hypertherm waterjetWebTolerance will develop (or will develop much faster) only in a circumstance where a drug places a demand on an organism's homeostatic mechanisms - Ex. anorexia in rats: tolerance develops faster when the drug is administered alongside food (homeostasis wants rat to eat) Behavioural Tolerance hypertherm waterjet pumpsWeb1 jan. 2011 · In the homeostatic and redundancy theory of tolerance and dependence, W. R. Martin (1968) proposed that tolerance and dependence are part of the same phenomena. He postulated that the neuroadaptive mechanisms that counteract an effect of the drug to produce drug tolerance persist even after the drug has been cleared. hypertherm welding suppliesWeb1 jul. 1991 · Search life-sciences literature (Over 39 million articles, preprints and more) hypertherm waterjet partsWeb29 jun. 2015 · Health is regulated by homeostasis, a property of all living things. Homeostasis maintains equilibrium at set-points using feedback loops for optimum functioning of the organism. Imbalances in homeostasis causing overweight and obesity are evident in more than 1 billion people. In a new theory, homeostatic obesity imbalance is … hypertherm washington