WebNanosuspension is a novel drug formulation for the delivery of hydrophobic drugs. The problem of medications that are poorly water-soluble and have low bioavailability is countered by nanosuspension technology. Solubility is a significant physiochemical element that influences drug absorption and therapeutic effectiveness.

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WebNov 25, 2024 · Abstract. The poor solubility of the antidiabetic drug gliclazide (Glc) is due to its hydrophobic nature. This research is aimed at improving Glc’s solubility and drug release profile, as well as at investigating additional benefits such as bioactivity and antioxidant activity, by forming binary complexes with HPβCD at different ratios (1 : 1, 1 : … WebGliclazide is a hydrophobic weak acid, insoluble in water and acidic pH and soluble towards neutral to alkaline pH. Variation in pH results in inconsistent and irregular release of drug ... The solubility of gliclazide is pH dependent increasing almost 3 fold from pH 7.0 to pH 8.3. TABLE 3 Dissolution profile in pH 6.8 Phosphate buffer laza food and beverage

Study of the solubilization of gliclazide by aqueous

WebMay 6, 2008 · The aim of the present study was to enhance the dissolution rate of gliclazide using its solid dispersions (SDs) with polyethylene glycol (PEG) 6000. The phase solubility behavior of gliclazide in presence of various concentrations of PEG 6000 in 0.1 N HCl was obtained at 37 °C. WebDec 18, 2024 · The GLZ−PPZ salt contains N−H⋅⋅⋅O=C (GLZ) and N−H⋅⋅⋅O=S (GLZ) hydrogen bonds between the protonated piperazine and the deprotonated gliclazide. 36 Solubility and dissolution experiments were conducted in a pH 7.4 phosphate buffer, and were found to follow the order GLZ−PPZ>GLZ−CAT>GLZ−RES>GLZ−PTSA>GLZ (see … WebGliclazide is almost insoluble in water, slightly soluble in alcohol, sparingly soluble in acetone, and freely soluble in chloroform and methylene chloride. kayak leeds liverpool canal