WebMitomycin C is a potent DNA crosslinker. A single crosslink per genome has shown to be effective in killing bacteria. This is accomplished by reductive activation of mitomycin to form a mitosene, which reacts successively via N - alkylation of two DNA bases. Both alkylations are sequence specific for a guanine nucleoside in the sequence 5'-CpG-3'. WebDescription: Mitomycin, a highly toxic antineoplastic antibiotic, selectively inhibits the synthesis of deoxyribonucleic acid (DNA) by alkylating DNA to produce DNA cross-linking (primarily with guanine and cytosine pairs).It also suppresses cellular ribonucleic acid (RNA) synthesis at high concentrations. Although it is not a cell cycle-specific agent, it is most …
DailyMed - MITOMYCIN injection, powder, lyophilized, for …
WebThe National Library of Medicine (NLM), on the NIH campus in Bethesda, Maryland, is the world's largest biomedical library and the developer of electronic information services that delivers data to millions of scientists, health professionals and members of the public around the globe, every day. Mitomycin C is a potent DNA crosslinker. A single crosslink per genome has shown to be effective in killing bacteria. This is accomplished by reductive activation of mitomycin to form a mitosene, which reacts successively via N-alkylation of two DNA bases. Both alkylations are sequence specific for a guanine nucleoside in the sequence 5'-CpG-3'. Mitomycin gel is an alkylating drug, meaning it inhibits the transcription of DNA into RNA, stoppi… preflower vs flower
bacillus calmette guerin regimen - National Library of Medicine …
WebDailyMed Drug Label, mitomycin, 2014. Recent clinical studies. Etiology. Primary Chemoablation of Low-Grade Intermediate-Risk Nonmuscle-Invasive Bladder Cancer … WebFDA label information for this drug is available at DailyMed. Use in Cancer. Mitomycin is approved to be used alone or with other drugs to treat: Gastric (stomach) and pancreatic … WebJan 3, 2024 · Mitomycin for Injection, USP is a sterile dry mixture of mitomycin and mannitol, which, when reconstituted with Sterile Water for Injection, provides a solution … scotch frost sold