WebBRD4, a major tandem-bromodomain-containing transcription regulator, has two isoforms. The long isoform (BRD4L) has an extended C terminus that binds transcription … WebOur BRD4 polyclonal, recombinant monoclonal and monoclonal antibodies are developed in Rabbit, Mouse and Goat. These antibodies have been verified by Knockdown and Relative expression to confirm specificity to BRD4. Find the BRD4 antibody that fits your needs.
Conditional Human BRD4 Knock-In Transgenic Mouse Genotyping …
WebMar 29, 2024 · Opposing Functions of BRD4 Isoforms in Breast Cancer. MYC protein stability is negatively regulated by BRD4. BRD4 prevents the accumulation of R-loops and protects against transcription-replication collision events and DNA damage. BRD4 promotes tumor progression and NF-kappaB/CCL2-dependent tumor-associated macrophage … WebMar 15, 2024 · BRD4, a major tandem-bromodomain-containing transcription regulator, has two isoforms. The long isoform (BRD4L) has an extended C terminus that binds transcription cofactors, while the short isoform (BRD4S) lacks this C-terminal extension. Unlike BRD4L, the role of BRD4S in gene transcription remains unclear. Here, we report … protection drainage board
The Long and the Short of BRD4: Two Tales in Breast …
WebJan 16, 2015 · BRD4S: BRD4 short isoform; BRD4L: BRD4 long isoform; BRD4C: Commercial BRD4 primer as positive control; CRC: colorectal cancer. 2.2. Colon Cancer Cell Proliferation Is Potently Inhibited by … WebJul 22, 2024 · BRD4 exists as two isoforms—a long isoform comprising the complete protein and a short isoform with only the N-terminal half, which was originally named as HUNK1 [ [ 4] ]. Unless otherwise stated, the focus of … WebBRD4 Short Isoform Interacts with RRP1B, SIPA1 and Components of the LINC Complex at the Inner Face of the Nuclear Membrane PLoS ONE Nov 2013 Recent studies suggest that BET inhibitors are ... protection dossier windows 10